T-cell receptor (TCR) recognizing Bordetella pertussis-derived peptide-MHC complexes (TCR-Bp-pMHC)

The T-cell receptor (TCR) recognizing Bordetella pertussis-derived peptide-MHC complexes is a specialized immune receptor responsible for identifying specific antigens from the bacterium that causes whooping cough. These TCRs are expressed on the surface of T lymphocytes and function by binding to fragments of B. pertussis proteins, such as pertussis toxin or pertactin, which are presented by Major Histocompatibility Complex (MHC) molecules on antigen-presenting cells [1][2]. This binding event is the critical first step in the adaptive immune response, leading to T-cell activation, proliferation, and the production of protective cytokines like interferon-gamma and interleukin-17 [3][4]. In clinical medicine, these TCR-pMHC interactions are the primary focus of pertussis vaccines, which aim to induce a robust and long-lasting population of memory T cells bearing these specific receptors [5]. Research into these complexes is essential for understanding why immunity wanes after acellular vaccination and for developing more effective, next-generation vaccines [6][7]. Furthermore, the characterization of these TCRs serves as a vital biomarker for assessing the cellular immune status of individuals against pertussis infection [8].

Other names

Bordetella pertussis-specific T-cell receptorPertussis-specific TCRTCR-pMHC complex (Bordetella pertussis)

Vaccines provide antigenic peptides that are processed and presented by MHC molecules; these complexes are recognized by the TCR, triggering the expansion of B. pertussis-specific memory T cells and orchestrating protective immunity [5][7].