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Target intelligence / Profile preview
T cell receptor gamma variable 7 (pseudogene) (TRGV7)
- Target
- TRGV7
- Molecular classification
- Pseudogene, T cell receptor superfamily, Immunoglobulin superfamily
01
Overview
T cell receptor gamma variable 7 (TRGV7) is classified as a pseudogene in humans and is located at chromosome 7p14. It is part of the T cell receptor gamma (TRG) gene family, which encodes the variable region of the gamma chain in the γδ T cell receptor; however, TRGV7 itself does not produce a functional protein. Pseudogenes like TRGV7 arise from gene duplication or retrotransposition events and carry sequence similarity to protein-coding genes but contain mutations or structural changes preventing translation into a functional protein. As such, TRGV7 has no established biological function, disease association, or therapeutic relevance and is not a druggable target. It may be referenced in immunogenetics studies and antibody diversity analyses, but it does not contribute to T cell receptor-mediated antigen recognition or signaling.
- Other names
- TCRGV7V1S7PT-cell receptor, gamma, variable region V7 (pseudogene)
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