T-cell receptor recognizing peptide-HLA-A*24:02 complex (TCR-pHLA-A*24:02)

The CD8+ T-cell receptor (TCR) recognizing peptide–HLA-A*24:02 complexes is a specialized immune receptor that mediates the recognition of intracellular antigens presented on the cell surface. HLA-A*24:02 is one of the most prevalent HLA class I alleles in East Asian populations, including approximately 60% of the Japanese population (Allele Frequency Net Database, 2024). These complexes consist of a 9-11 amino acid peptide derived from endogenous proteins bound to the HLA-A*24:02 molecule, which is then recognized by the TCR on CD8+ cytotoxic T lymphocytes (PubMed: 31515463). This recognition is a cornerstone of the adaptive immune response against viral infections and malignancies. In therapeutic contexts, this complex is targeted by TCR-engineered T-cell (TCR-T) therapies, such as TBI-1301, which targets NY-ESO-1 peptides presented by HLA-A*24:02 (Takara Bio, 2023). The interaction triggers T-cell activation, leading to the secretion of cytokines like IFN-gamma and the direct lysis of target cells via the perforin/granzyme pathway (Nature Reviews Immunology, 2021). Clinical applications focus on cancers expressing specific antigens like WT1, MAGE-A4, or NY-ESO-1 in HLA-A*24:02-positive patients (ClinicalTrials.gov: NCT04729543).

Other names

HLA-A*24:02-restricted T-cell receptorPeptide-HLA-A*24:02 complexpMHC-A*24:02CD8+ T-cell receptor recognizing peptide-HLA-A*2402 complexes

Specific binding of engineered or endogenous T-cell receptors to peptide-HLA-A*24:02 complexes on target cells, inducing T-cell activation, cytokine release, and cytotoxic lysis of the target cell.