T cell receptor specific for KRAS G12V mutant peptide presented by HLA-A*02:01 (KRAS G12V/HLA-A*02:01-specific TCR)

The T cell receptor specific for KRAS G12V mutant peptide presented by HLA-A*02:01 is a highly specialized surface protein expressed on T lymphocytes. This receptor recognizes a peptide derived from the KRAS protein with a glycine-to-valine substitution at codon 12 (G12V), a common oncogenic mutation in various cancers. The peptide must be processed and presented by the HLA-A*02:01 molecule on the tumor cell surface for the TCR to bind. When T cells bearing this receptor encounter and recognize the mutant peptide-HLA complex, they initiate an immune response, leading to targeted killing of the cancer cell. Such TCRs are being developed as engineered cell therapies and represent a promising approach to treating cancers driven by the KRAS G12V mutation, especially in patients with the HLA-A*02:01 allele.

Other names

T lymphocyte receptor specific for KRAS G12V/HLA-A*02:01KRAS G12V mutant-specific TCRKRAS G12V neoantigen-specific TCR (HLA-A*02:01)

Recognition of mutated KRAS G12V peptide presented by HLA-A*02:01\nInitiation of T cell cytotoxic response against KRAS G12V–expressing tumor cells\nInduction of tumor cell apoptosis via cytolytic granules (perforin, granzyme B) and cytokine production (e.g., IFN-γ)