Target protein (varies by specific PROTAC)

The "target protein" in the context of PROTACs refers to any intracellular protein that a given PROTAC molecule is designed to bind and induce degradation. The identity of this target varies depending on the specific disease or biological process being addressed, as each PROTAC is engineered with a ligand that selectively binds its intended target protein. This approach enables selective elimination—including previously undruggable targets—by harnessing endogenous cellular machinery rather than relying solely on enzymatic inhibition or occupancy-based antagonism.

Other names

PROTAC targetProtein of interest (POI)Degradation target

PROTAC-mediated degradation via E3 ubiquitin ligase recruitment and proteasomal degradation