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Target intelligence / Profile preview
Taste 2 receptor member 6, pseudogene (TAS2R6P)
- Target
- TAS2R6P
- Molecular classification
- Pseudogene, G protein-coupled receptor (family ancestor), Receptor (family ancestor)
01
Overview
Taste 2 receptor member 6, pseudogene (*TAS2R6P*), is a non-functional gene in humans belonging to the family of bitter taste receptors known as TAS2Rs, which are typically G protein-coupled receptors responsible for the detection of bitter compounds. TAS2R6P arose from the loss of function of an ancestral gene and is now classified as a pseudogene, meaning it does not encode an active receptor and has no known biological or pharmaceutical function in humans. Variation in *TAS2R6P* is notable in population genomics and evolutionary studies, as its genetic polymorphisms may be in linkage disequilibrium with nearby functional genes such as *TAS2R5*, which is under selective pressure in some populations[1]. While functional bitter taste receptors like TAS2R5 mediate bitter taste perception and possibly extra-oral functions, *TAS2R6P* itself is a genomic relic of this receptor pathway, not a participant in taste or other signaling.
- Other names
- T2R06T2R6PS3TAS2R6bitter taste receptor PS3taste receptor, type 2, member 6, pseudogene
02
Mechanism of action
None (not a functional protein in humans)
03
Biological functions
None (in humans, as a pseudogene; functional in ancestral or other species)Historical role in bitter taste perception (suggested by sequence relation to active receptors)[1][2][3]
04
Disease associations
None directly; TAS2R6P itself does not participate in disease due to its lack of function.May serve as a genetic marker for evolutionary studies or population genetics[1]
05
Safety considerations
None (no therapeutic interventions, as it is not a functional gene)[1][5]
06
Biomarkers
Polymorphisms in *TAS2R6P* may be used in population genetics or evolutionary biology studies[1], but not for clinical applications.
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