Taste 2 receptor member 64, pseudogene (TAS2R64P)

Taste 2 receptor member 64, pseudogene (TAS2R64P) is classified as a bitter taste receptor gene in the extended TAS2R family. Unlike typical bitter taste receptors, TAS2R64P is annotated as a pseudogene in humans and does not produce a functional receptor protein due to genetic interruptions (such as frameshift mutations or premature stop codons). Bitter taste receptors of the TAS2R family normally serve as G protein-coupled receptors mediating detection of bitter compounds, thus aiding in the avoidance of potentially harmful substances. However, TAS2R64P (as with other TAS2R pseudogenes) has lost its ability to encode a responsive receptor, and there is no evidence that this pseudogene binds bitter compounds or participates in taste signaling. As such, it is not considered a therapeutic target, does not interact with drugs, is not used as a biomarker, and holds no known disease relevance. The gene is sometimes confused with functional family members, so careful distinction is warranted.

Other names

T2R64T2R64PPS2taste receptor, type 2, member 19 pseudogenetaste receptor, type 2, member 64, pseudogene