Taste receptor type 2 member 63, pseudogene (TAS2R63P)

Taste 2 receptor member 63, pseudogene (TAS2R63P), also referred to as PS6, T2R63, taste receptor, type 2, member 63, pseudogene, describes a human pseudogene related to the bitter taste receptor family[3]. This gene is designated as a pseudogene, meaning it is a non-functional copy resulting from the loss of function during evolution, and is not considered to encode a functional receptor protein[3]. Taste receptor type 2 member 63, pseudogene, is a non-functional genomic sequence related to the human bitter taste receptor family (TAS2Rs). TAS2Rs are members of the G protein-coupled receptor family and mediate signal transduction for the perception of bitter compounds, playing a role in dietary choices and avoidance of toxins[1]. The TAS2R gene family includes 25 functional loci and at least 8–11 pseudogenes in humans, with pseudogenes such as TAS2R63P representing evolutionary loss of taste receptor function[3]. While functional TAS2R receptors participate in taste signal pathways by activating G proteins such as α-gustducin, pseudogenes like TAS2R63P have lost coding ability and do not produce active proteins or fulfill biological roles related to taste perception[3][1][2]. In summary: TAS2R63P is a pseudogene and not a therapeutic target, but can be referenced as a genomic remnant associated with the bitter taste receptor family. Its functional relatives play significant roles in taste perception, but this particular sequence is not a target for therapeutic intervention, drug interaction, or disease association[3][1].

Other names

PS6T2R63taste receptor, type 2, member 63, pseudogeneTAS2R63P

Not applicable. No mechanism of action for a pseudogene.