TATA-box binding protein associated factor, RNA polymerase I subunit B (TAF1B)

TATA-box binding protein associated factor, RNA polymerase I subunit B (TAF1B), is a protein component of the transcription factor SL1, which is essential for the initiation of transcription by RNA polymerase I. SL1, a complex composed of TATA-binding protein (TBP) and three TBP-associated factors (TAFs), binds to the rDNA core promoter and positions RNA polymerase I for rRNA gene transcription. TAF1B acts as a GTF2B/TFIIB-like factor, participating in pre-initiation complex assembly and facilitating recruitment and regulation of RNA polymerase I, possibly by direct interaction with transcription factors such as RRN3. Evidence for TAF1B's direct role as a therapeutic target or drug-interaction partner is currently lacking[1][2][8].

Other names

TATA box-binding protein-associated factor RNA polymerase I subunit BTAFI63RAFI63RAF1BSL1TBP-associated factor 1BTATA Box Binding Protein (TBP)-Associated Factor, RNA Polymerase I, B, 63kDaTranscription initiation factor SL1/TIF-IB subunit BRNA polymerase I-specific TBP-associated factor 63 kDaMGC:9349[2]