TATA-box binding protein associated factor 6 like (TAF6L) (TAF6L)

TATA-box binding protein associated factor 6-like (Taf6l) is a key component of the SAGA (Spt-Ada-Gcn5 acetyltransferase) complex, a multi-subunit co-activator involved in transcriptional regulation through histone acetylation and chromatin remodeling (UniProt Q924H9). The mouse Taf6l pre-mRNA is the initial transcript produced from the Taf6l gene, which must undergo splicing and processing to generate the mature mRNA required for protein synthesis (NCBI Gene ID: 225891). In murine models, Taf6l has been shown to be essential for maintaining the pluripotency of embryonic stem cells and regulating the expression of c-Myc target genes (PubMed: 29030453). Although the SAGA complex is a potential area for therapeutic intervention in cancer due to its role in gene expression, Taf6l pre-mRNA itself is not currently a validated therapeutic target in humans. Most research involving this specific mouse transcript is focused on understanding developmental biology and transcriptional networks rather than drug development. Consequently, there are no known drugs that specifically interact with the Taf6l pre-mRNA or protein at this time.

Other names

Taf6lPaf65aTATA-box binding protein-associated factor 6-likePCAF-associated factor 65 alphaMouse Taf6l pre-mRNA

Not applicable