TEA domain family member 2 (TEAD2) (TEAD2)

TEA domain family member 2 (TEAD2) mRNA is the transcript encoding the TEAD2 protein, a member of the TEA domain family of transcription factors [1]. It plays a pivotal role in the Hippo signaling pathway, where it serves as the primary DNA-binding platform for the transcriptional co-activators YAP and TAZ [2]. The resulting YAP/TAZ-TEAD complex regulates the expression of genes essential for cell proliferation, survival, and organ size control [3]. In the context of oncology, TEAD2 is frequently overexpressed and is a key driver of the epithelial-mesenchymal transition (EMT), which facilitates cancer cell invasion and metastasis [2]. Targeting TEAD2 at the mRNA level using technologies such as antisense oligonucleotides (ASOs) or small interfering RNAs (siRNAs) provides a method to downregulate the protein and disrupt oncogenic signaling [3]. This approach is particularly valuable in cancers where the Hippo pathway is dysregulated, such as mesothelioma, hepatocellular carcinoma, and breast cancer [4]. While small molecule inhibitors targeting the TEAD protein's palmitoylation pocket are currently the primary focus of clinical development, mRNA-directed therapies offer a distinct mechanism for silencing this transcription factor [4]. Therapeutic challenges include ensuring specific delivery to tumor tissues and managing potential toxicities related to the Hippo pathway's role in normal tissue homeostasis and development [1, 3].

Other names

TEF-4Transcriptional enhancer factor 4ETFTEA domain family member 2 mRNA

Inhibition of the Hippo signaling pathway by reducing TEAD2 protein levels through mRNA degradation or by blocking the interaction between TEAD2 and its co-activators YAP/TAZ, thereby suppressing oncogenic gene transcription.