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Target intelligence / Profile preview
TEA Domain Transcription Factor (TEAD Family) (TEAD)
- Target
- TEAD
- Molecular classification
- Transcription factor
01
Overview
The TEA domain transcription factors (TEADs) are a family of transcription factors that regulate gene expression related to cell proliferation, development, and tumorigenesis. They bind DNA via the TEA domain and interact with cofactors like YAP/TAZ to activate transcription. Dysregulation of TEADs is implicated in various diseases, including cancer and vascular disease, making them therapeutic targets. Current strategies focus on disrupting YAP/TAZ-TEAD interaction with small-molecule inhibitors.
- Other names
- Transcriptional Enhancer Factor 1TCF-13TEAD1TEAD2TEAD3TEAD4
02
Mechanism of action
Inhibition of YAP/TAZ-TEAD interaction via targeting the palmitate-binding pocket in the TEAD C-terminal region.
03
Biological functions
DNA bindingTranscription regulationCell proliferationCell differentiationDevelopmentTumorigenesisAdipogenesis
04
Disease associations
Cancer progressionMetastasisStemnessDrug resistanceVascular occlusion
05
Safety considerations
Context-dependent effects in different tissuesPotential for off-target effectsInhibition of essential developmental processes
06
Interacting drugs
TM2
2 more in the full profile.
07
Biomarkers
YAP/TAZ expression levelsTEAD expression levelsCyclin B1/B/G/O family members expression
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