TEA domain transcription factor 2 (TEAD2) (TEAD2)

TEA domain transcription factor 2 (TEAD2), also known as Transcriptional enhancer factor TEF-4, is a member of the TEAD family of transcription factors that serve as the primary nuclear effectors of the Hippo signaling pathway [17, 28]. It regulates gene expression by binding to the MCAT element in promoters and recruiting co-activators such as YAP (Yes-associated protein) and TAZ (Transcriptional co-activator with PDZ-binding motif) [2, 29]. TEAD2 is crucial for early embryonic development, particularly in neural tube closure and the maintenance of stem cell pluripotency [17, 20]. In many human cancers, including hepatocellular carcinoma and pancreatic cancer, TEAD2 is overexpressed and drives tumor progression, metastasis, and resistance to apoptosis by activating oncogenic transcriptional programs [28, 29]. Therapeutic targeting of TEAD2 is currently being explored through the development of small-molecule inhibitors that either block its auto-palmitoylation pocket or disrupt its interaction with YAP/TAZ co-activators [1, 22].

Other names

Transcriptional enhancer factor TEF-4TEF-4ETFETEF-1TEA domain family member 2Transcriptional enhancer factor 4

Inhibition of TEAD auto-palmitoylation and disruption of the TEAD-YAP/TAZ transcriptional complex interaction.