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Target intelligence / Profile preview
Testis expressed 14, intercellular bridge forming factor (TEX14)
- Target
- TEX14
- Molecular classification
- Scaffold protein required for intercellular bridge formation in germ cells (not a receptor, enzyme, transporter, ion channel, or transcription factor), Sometimes classified as a “protein kinase–like” protein, but lacks detectable kinase activity
01
Overview
Testis expressed 14, intercellular bridge forming factor (TEX14) is a scaffolding protein critically required for the formation and maintenance of intercellular bridges between germ cells during spermatogenesis. It localizes to intercellular bridges formed after incomplete cytokinesis, ensuring cytoplasmic communication and synchronization among developing sperm. TEX14 loss-of-function mutations cause male-specific infertility due to the absence of these bridges, leading to arrest of spermatogenesis before meiotic division. TEX14 is not a protein kinase, despite bearing a kinase-like domain, and is instead believed to serve as a scaffold in bridge assembly. There are no drugs that target TEX14, and it is not considered a conventional therapeutic target, though it may serve as a biomarker in certain settings, such as male infertility or as a cancer/testis antigen in oncology.
- Other names
- Inactive serine/threonine-protein kinase TEX14SgK307CT113Cancer/testis antigen 113Testis-expressed protein 14Testis expressed sequence 14
02
Mechanism of action
Not applicable. TEX14 is not a therapeutic target for any approved or investigational agents.
03
Biological functions
Intercellular bridge formation during germ cell divisionSpermatogenesis and germ cell communicationMaintenance and stability of intercellular bridgesKinetochore-microtubule attachment during mitosis
04
Disease associations
Male infertility: Mutations or loss of TEX14 block spermatogenesis and cause infertilitySpermatogenic failureListed as a “cancer/testis antigen” (implicated as a potential marker in certain cancers, but not as a causal or direct therapeutic target)
05
Safety considerations
Not applicable. No known pharmacological safety concerns, as it is not a drug target.
06
Interacting drugs
None known. There are no drugs presently described to directly target or modulate TEX14
07
Biomarkers
Possible use as a biomarker in male infertility and cancer/testis antigen studies, but not widely used clinically
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