Target intelligence / Profile preview

Testis expressed transcript, Y-linked 10 (TTTY10)

Target
TTTY10
Molecular classification
Long non-coding RNA (lncRNA), Other (non-coding RNA)
01

Overview

Testis expressed transcript, Y-linked 10 (TTTY10) is a long non-coding RNA gene located on the human Y chromosome, specifically restricted to males[1][3][5]. Like other lncRNAs, TTTY10 does not code for a protein but is transcribed as RNA. Bioinformatics and expression studies indicate that TTTY10 is co-expressed with genes involved in signal transduction, transcription regulation, cell adhesion, and differentiation, suggesting potential roles in gene regulatory networks, possibly impacting development or disease, particularly in male-specific tissues and contexts[4]. There is preliminary evidence associating TTTY10 with colorectal cancer progression based on co-expression with differentially expressed genes, implying it could serve as a molecular marker or have a regulatory role in tumor biology, but its precise biological function and clinical implications remain largely unknown[4][6][8][10]. No approved drugs or therapeutic interventions currently target TTTY10.

Other names
NCRNA00133TTY10lnc-KDM5D-4non-protein coding RNA 133testis-specific transcript, Y-linked 10 (non-protein coding)transcript Y 10
02

Mechanism of action

Not applicable (no drugs target TTTY10 directly)

03

Biological functions

Regulation of transcriptionSignal transductionCell adhesionCell differentiationDevelopment
04

Disease associations

Cancer (notably colorectal cancer; co-expression in tumor context)
05

Safety considerations

No data on therapeutic targeting; as a lncRNA, off-target and unknown functional consequences are general considerations
06

Biomarkers

Potential biomarker in colorectal cancer, based on co-expression analyses

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