Testis expressed transcript, Y-linked 18 (TTTY18)

Testis expressed transcript, Y-linked 18 (TTTY18) is a long noncoding RNA (lncRNA) located on the Y chromosome (Yp11.2), first annotated based on its expression in the testis, though its functional roles extend to other biological contexts[5][7]. It does not encode a protein but participates in the regulation of gene expression, especially in the context of environmental stress responses and cancer biology. Elevated TTTY18 expression is observed in certain cancers, particularly colorectal cancer, where it appears related to tumor progression marker profiles. Its expression is responsive to environmental pollutants and downregulated by anti-cancer phytochemicals like genistein. The mechanistic details of TTTY18 function are not fully established, and it is not currently classified as a druggable therapeutic target[5][1][3][7].

Other names

NCRNA00143non-protein coding RNA 143

Downregulation of TTTY18 by genistein is associated with reduced cell viability and migration in cancer cells, and reduced tumor marker expression, suggesting TTTY18 may be involved in oncogenic pathways affected by genistein