Testis specific protein, Y-linked 14, pseudogene (TSPY14P)

Testis specific protein, Y-linked 14, pseudogene (TSPY14P) is a human gene annotated as a pseudogene, meaning that it does not code for a functional protein and is generally considered non-functional at the molecular level[1][3][5][6][7][8]. While related TSPY genes (such as TSPY1) are protein-coding with known roles as male-specific cancer-testis antigens and have functions in spermatogenesis and oncogenesis, TSPY14P differs in that it is a non-coding pseudogene locus on the Y chromosome. There is no evidence that TSPY14P itself serves as a therapeutic target (e.g., receptor, enzyme, transporter) or plays direct roles in biological function or disease[1][5][6][7][8]. No drug interactions or biomarker utilities are described for this entity. This entry is considered "incorrect" in the context of drug discovery/target databases because it is a pseudogene and not an actionable molecular target. The confusion sometimes arises because the functional canonical TSPY protein family (such as TSPY1) has been studied in oncology, but TSPY14P, like many annotated TSPY pseudogenes, is nonfunctional and not a protein, receptor, or actionable target[1][5][8]. Molecular databases (e.g., HGNC, Ensembl) and pharmacogenomics resources confirm TSPY14P as a pseudogene with no alternate names/symbols of functional relevance[8].

Other names

TSPYP4Testis specific protein, Y-linked pseudogene 4