Testis specific protein Y-linked 18, pseudogene (TSPY18P)

Testis specific protein Y-linked 18, pseudogene (TSPY18P) is a pseudogene member of the Y-linked testis specific protein (TSPY) gene family. While functional TSPY genes, such as TSPY1, are protein-coding and have established biological and pathological roles—especially as cancer-testis antigens associated with cell proliferation, oncogenic processes, and germ cell tumors[1][4][7]—TSPY18P itself is annotated as a pseudogene. Pseudogenes are genomic DNA sequences similar to normal genes but are nonfunctional; they may arise from gene duplication or retrotransposition, and typically do not encode functional proteins. There are many TSPY pseudogenes clustered with functional paralogs within the human genome[7]. Neither biological function, disease association, nor drug interaction is ascribed to TSPY18P, and it is not recognized as a therapeutic target. Note: The designation “testis specific protein Y-linked 18, pseudogene” or TSPY18P does not refer to an active protein or receptor, but rather to a nonfunctional genetic element; therefore, it should not be considered an actionable target. Key Notes: - “TSPY1” is the canonical protein-coding gene with known roles; TSPY18P refers specifically to a pseudogene variant, without protein product or established biological function[7]. - TSPY pseudogenes, such as TSPY18P, are annotated in gene clusters but are not therapeutically actionable nor used as biomarkers[7]. - The mouse ortholog for TSPY is also a pseudogene and nonfunctional[1][7]. - There are no known aliases for TSPY18P beyond its systematic pseudogene designation. This entry is “incorrect” for most biomedical targeting purposes because it does not represent an active, functional protein or recognized drug or antigen target.

Other names

TSPY18P