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Thioredoxin reductase, Ribonucleotide reductase

Molecular classification: Enzyme, Oxidoreductase

Overview

Thioredoxin reductase and ribonucleotide reductase are distinct enzymes, both considered important therapeutic targets, primarily classified as oxidoreductases involved in redox regulation and DNA synthesis, respectively. They are linked in cellular metabolism—thioredoxin reductase regenerates thioredoxin, which in turn supplies reducing equivalents to ribonucleotide reductase. Both have well-characterized roles in cancer and other diseases and are targets for chemotherapy and other drug classes.

Biological functions

Redox regulationDNA synthesis

Disease associations

CancerCardiovascular diseaseNeurodegenerative diseaseInflammationInfectionOther (redox disorders)Viral infectionBacterial infectionOther (mutagenesis, immune deficiency)

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