Threonine aldolase 1, pseudogene (THA1P)

Threonine aldolase 1, pseudogene (THA1P, also known as GLY1) refers to a human gene located on chromosome 17q25 that historically encoded the enzyme threonine aldolase. Threonine aldolase catalyzes the conversion of L-threonine to glycine and acetaldehyde and participates in amino acid metabolism, but in humans the gene has undergone mutations that result in frameshifts and premature stop codons. As a consequence, the gene is not transcribed or translated, and no functional enzyme is produced. The mouse ortholog is expressed and produces active threonine aldolase. Humans therefore lack true threonine aldolase activity; any minor catabolic activity seen in humans is attributed to other enzymes (e.g., serine hydroxymethyltransferase)[1][2][3][4][5]. - In non-human species such as mice, frogs, and zebrafish, functional threonine aldolase has biological relevance and participates in L-threonine catabolism, impacting glycine biosynthesis[3][5]. - In yeast and bacteria, GLY1 or THA1 orthologs perform essential metabolic reactions and have been studied for their structural and enzymatic properties[1][5][6]. - The human gene is confirmed by multiple sources to be a pseudogene, with no evidence for transcription or translation into a functional protein[2][3][4][5][7].

Other names

GLY1threonine aldolase pseudogeneTHA1P