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Target intelligence / Profile preview
Thymidine Kinase (Herpes Simplex Virus Type 1) (HSV-1 TK)
- Target
- HSV-1 TK
- Molecular classification
- Enzyme, Kinase
01
Overview
Thymidine kinase from herpes simplex virus type 1 (HSV-1 TK) is a viral enzyme that catalyzes the phosphorylation of thymidine to thymidine monophosphate (dTMP), essential for viral DNA replication. It has broad substrate specificity, including pyrimidine and purine analogs like acyclovir and ganciclovir. HSV-1 TK is a target for antiviral therapy and is used in suicide gene therapy for cancer treatment. Drug resistance can arise from mutations in the UL23 gene.
- Other names
- HSV-1 Thymidine KinaseHerpes Simplex Virus Type 1 Thymidine KinaseUL23TK
02
Mechanism of action
Phosphorylation of nucleoside analogs, leading to chain termination or inhibition of DNA polymerase
03
Biological functions
PhosphorylationNucleotide salvageViral DNA synthesis
04
Disease associations
Herpes simplex infectionsCancer (gene therapy)
05
Safety considerations
Drug resistance development due to mutations in UL23Off-target effects in gene therapy applications
06
Interacting drugs
Acyclovir
4 more in the full profile.
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