Target intelligence / Profile preview

Thymidine Kinase 1, Cytosolic (TK1)

Target: TK1
Molecular classification: Enzyme, Kinase

Overview

Thymidine kinase 1, cytosolic (TK1), is a cell-cycle-regulated enzyme that catalyzes the phosphorylation of thymidine to dTMP. This reaction is essential for dTTP synthesis, a building block for DNA replication and repair. TK1 activity peaks during S phase and is tightly regulated. Elevated serum TK1 levels are associated with increased cellular proliferation in cancers.

Other names: Thymidine kinase, cytosolic

Mechanism of action

Phosphorylates thymidine to form dTMP, a crucial step in dTTP synthesis and DNA replication. Also activates some prodrugs through phosphorylation.

Biological functions

Nucleotide metabolismDNA synthesisCell cycleCell proliferation

Disease associations

Cancer

Safety considerations

Elevated TK1 as a marker of increased cellular proliferation can indicate cancer progression or recurrence.

Interacting drugs

AZT

1 more in the full profile.

Biomarkers

Elevated serum TK1 levels

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