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Target intelligence / Profile preview
Trained Immunity Induction via Pattern Recognition Receptor (for BCG) (N/A)
- Target
- N/A
- Molecular classification
- Innate Immune Receptor-mediated Pathway, Pattern Recognition Receptor signaling, Epigenetic regulation, Metabolic reprogramming
01
Overview
Trained immunity refers to the phenomenon where innate immune cells develop a long-lasting enhanced response after exposure to certain stimuli, including vaccines like BCG. This process is mediated by epigenetic and metabolic reprogramming of innate immune cells via pattern recognition receptors (PRRs) such as TLR2, TLR4 and NOD2 upon recognition of mycobacterial PAMPs. The net effect is an enhanced non-specific response to subsequent infections, driven by increased production of pro-inflammatory cytokines and improved innate defenses.
- Other names
- BCG-induced Trained ImmunityPattern Recognition Receptor-mediated Trained Immunity (BCG)Innate Immune Memory Induction (BCG)PRR-mediated Trained Immunity
02
Mechanism of action
Activation of PRRs (NOD2, TLR2, TLR4) by BCG leading to intracellular signaling, epigenetic remodeling, metabolic rewiring, and enhanced cytokine production upon secondary stimulation.
03
Biological functions
Immune responseInflammationPattern recognitionSignal transductionEpigenetic modificationMetabolic reprogrammingCytokine production
04
Disease associations
InfectionVaccinationImmune modulation
05
Safety considerations
Excessive inflammationPotential for immune dysregulationVariability in response based on individual genetic and environmental factors
06
Interacting drugs
BCG vaccine
2 more in the full profile.
07
Biomarkers
CD14 expressionCD11b expressionTLR4 expressionPro-inflammatory cytokine levels (TNF-alpha, IL-1beta, IL-6)
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