Transcription factor and kinase signaling network (RELA, JUN, FOS, MAPK1) (RELA/JUN/FOS/MAPK1)

This entry refers to a group of four distinct signaling proteins that are central to cellular responses to growth factors and inflammatory cytokines: RELA (p65), JUN (c-Jun), FOS (c-Fos), and MAPK1 (ERK2). RELA is a primary subunit of the NF-kappaB transcription factor complex, which plays a pivotal role in the inflammatory response and cell survival pathways (UniProt Q04206). JUN and FOS are components of the Activator Protein-1 (AP-1) transcription factor complex, which converts extracellular signals into changes in gene expression related to proliferation and apoptosis (UniProt P05412, P01100). MAPK1, also known as ERK2, is a serine/threonine kinase that serves as a critical node in the MAPK/ERK pathway, phosphorylating numerous targets including JUN and FOS to promote cell cycle progression (UniProt P28482). Together, these molecules form a highly interconnected signaling network frequently dysregulated in human cancers and chronic inflammatory diseases. Because this target string represents multiple distinct proteins rather than a single therapeutic target or a single stable biochemical complex, it is categorized as a multi-target signaling set.

Other names

NF-kappaB p65 subunitc-Junc-FosExtracellular signal-regulated kinase 2ERK2AP-1 complex componentsMAPK/ERK pathway components

Inhibition of mitogen-activated protein kinase activity (MAPK1), inhibition of proteasomal degradation of IkappaB to prevent RELA nuclear translocation, and disruption of AP-1 (JUN/FOS) transcriptional activity.