Transforming growth factor beta 1 mRNA (TGFB1 mRNA) (TGFB1 mRNA)

Transforming growth factor beta 1 (TGF-beta1) mRNA is the transcript of the TGFB1 gene that encodes the TGF-beta1 protein, a multifunctional cytokine belonging to the transforming growth factor beta superfamily. This mRNA serves as a critical regulatory point for the production of TGF-beta1, which governs essential cellular processes including proliferation, differentiation, and the synthesis of extracellular matrix components (UniProt P01137). In various pathologies, the overexpression of TGF-beta1 mRNA leads to excessive protein production, driving the progression of chronic fibrotic diseases in the lungs, liver, and kidneys, as well as promoting immune evasion and metastasis in advanced cancers (PubMed: 28453473). As a therapeutic target, TGF-beta1 mRNA is addressed using nucleic acid-based technologies such as antisense oligonucleotides (ASOs) and small interfering RNAs (siRNAs) to selectively silence gene expression. For instance, ISTH0036 is an ASO designed to bind to TGF-beta1 and TGF-beta2 mRNA to prevent their translation in ophthalmic and oncological indications (Isarna Therapeutics, 2023). By targeting the mRNA rather than the protein, these therapies aim to achieve more durable and specific inhibition of the TGF-beta signaling pathway. However, therapeutic development faces challenges related to the pleiotropic nature of TGF-beta1, where systemic inhibition may lead to unintended inflammatory responses or impaired tissue repair (PubMed: 21641392).

Other names

TGF-beta-1 mRNATGFB1 transcriptTransforming growth factor beta-1 messenger RNA

Antisense-mediated mRNA degradation and RNA interference-mediated gene silencing