Transforming growth factor beta messenger RNA 3' untranslated region (TGF-β mRNA 3'UTR)

The TGF-β mRNA 3'UTR is a critical regulatory region of the messenger RNA encoding Transforming Growth Factor beta isoforms (TGF-β1, TGF-β2, and TGF-β3). This region contains various cis-acting elements, such as AU-rich elements (AREs) and microRNA (miRNA) binding sites, which control the stability and translation efficiency of the mRNA. In many pathological conditions, including advanced cancers and fibrotic diseases, TGF-β is overexpressed, leading to immunosuppression, epithelial-mesenchymal transition (EMT), and excessive extracellular matrix deposition. Therapeutic strategies targeting the TGF-β mRNA, including antisense oligonucleotides (ASOs) like Trabedersen and ISTH0036, aim to downregulate TGF-β production at the genetic level. These agents bind to the mRNA (often targeting regulatory regions like the 3'UTR or coding sequences) to induce degradation or block translation, thereby reversing the pro-tumorigenic and pro-fibrotic effects of the cytokine.

Other names

TGF-beta 3'UTRTGFB1 3'UTRTGFB2 3'UTRTGFB3 3'UTRTransforming growth factor beta 1 messenger RNA 3' untranslated regionTransforming growth factor beta 2 messenger RNA 3' untranslated region

Antisense inhibition (RNase H-mediated degradation), Steric blocking of translation, Modulation of mRNA stability