Transforming growth factor beta receptor type 2 mRNA 3' untranslated region (TGFBR2 mRNA 3'UTR)

The Transforming growth factor beta receptor type 2 (TGFBR2) mRNA 3' untranslated region (3'UTR) is a critical regulatory segment of the TGFBR2 transcript that controls the expression of the TGF-beta type II receptor. This region serves as a primary site for post-transcriptional regulation, containing multiple binding motifs for microRNAs (miRNAs) and RNA-binding proteins that influence mRNA stability and translation (PMID: 21475224). In many oncogenic contexts, such as colorectal and gastric cancers, the TGFBR2 3'UTR is targeted by overexpressed miRNAs like miR-21 and miR-106b, which silence the receptor and allow cells to escape TGF-beta-mediated growth inhibition (PMID: 24651010). Mutations or alternative polyadenylation within this 3'UTR can also lead to the loss of these regulatory sites, contributing to aberrant signaling and disease progression (PMID: 29335523). As a therapeutic target, the TGFBR2 3'UTR is being investigated for RNA-targeted interventions, including antisense oligonucleotides and miRNA modulators, designed to restore tumor-suppressive TGF-beta signaling. Understanding the structural and sequence variations in this region is essential for developing precision medicines that address receptor downregulation in cancer and other fibroproliferative disorders (NCBI Gene ID: 7048).

Other names

TGF-beta receptor type II mRNA 3'UTRTGFBR2 3'UTRTGFBR2 3-prime untranslated regionTransforming growth factor-beta receptor type II 3'UTR

Modulation of TGFBR2 protein expression through competitive binding or degradation of mRNA, typically by inhibiting oncogenic microRNAs that target this region or using antisense sequences to stabilize/destabilize the transcript.