Transient receptor potential cation channel subfamily C member 3, Transient receptor potential cation channel subfamily C member 6, Transient receptor potential cation channel subfamily C member 7 (TRPC3, TRPC6, TRPC7)

The transient receptor potential cation channel subfamily C members 3, 6, and 7 (TRPC3, TRPC6, TRPC7) are non-selective calcium-permeable cation channels belonging to the TRPC superfamily. They share high sequence and structural similarity, each forming tetrameric channel complexes in the plasma membrane. Activation typically occurs via diacylglycerol in the phospholipase C signaling pathway, making them important effectors of G protein-coupled and tyrosine kinase receptor signaling. These channels regulate calcium influx into excitable and non-excitable cells and are key in vascular, neuronal, and kidney physiology. Dysregulation or mutation of these channels, particularly TRPC6, is implicated in diseases including cardiac hypertrophy, glomerular kidney disease, and certain neurological disorders. Their redundancy and overlapping expression create challenges for selective drug development and for dissecting their specific physiological roles[2][5][6][7].

Other names

TRP-3TRP-6TRP-7TRPC3/6/7 subfamilycanonical TRP channels

Channel blockers/inhibitors: Inhibit ion flow through the channel, reducing pathologic Ca²⁺ influx Modulators: Modulate channel gating, influence receptor-activated cellular responses