Transient receptor potential cation channel subfamily C member 5 (TRPC5) (TRPC5)

Transient receptor potential cation channel subfamily C member 5 (TRPC5) is a calcium-permeable, non-selective cation channel that plays a pivotal role in both the central nervous system and the renal system [1][2]. In the brain, TRPC5 is highly expressed in the amygdala, where it modulates calcium signaling essential for fear-related behaviors and emotional responses [3]. In the kidney, TRPC5 is located in podocytes, where its overactivation—often triggered by Rac1—leads to the breakdown of the actin cytoskeleton and subsequent damage to the filtration barrier [4]. This pathological process is a hallmark of focal segmental glomerulosclerosis (FSGS) and other chronic kidney diseases characterized by proteinuria [5]. Consequently, TRPC5 has emerged as a significant therapeutic target, with small-molecule inhibitors like GFB-887 being developed to protect kidney function by preventing podocyte loss [6]. Additionally, TRPC5 antagonism is being investigated for the treatment of anxiety and depression due to its role in limbic system excitability [7].

Other names

TRP5CCE2HTRP5Transient receptor protein 5rTRPC5Short transient receptor potential channel 5

Small molecule inhibition of the TRPC5 cation channel to prevent calcium-mediated cellular damage and stabilize the actin cytoskeleton.