Translocated promoter region, nuclear basket protein (TPR)

Translocated promoter region, nuclear basket protein (TPR) is a large, evolutionarily conserved nucleoporin forming an essential structural component of the nuclear basket on the nucleoplasmic side of the nuclear pore complex (NPC)[1][2][3][5]. TPR directly interacts with other NPC components, particularly Nup153, anchoring it to the NPC[4][6]. Its major biological functions include providing a structural scaffold for the NPC, facilitating export of mRNAs and some proteins, contributing to mRNA quality control, and supporting mitotic spindle checkpoint signaling[1][2][5][6]. Genomic rearrangements generating TPR fusion proteins (typically with kinase domains of proto-oncogenes like MET, RAF, or TRK) contribute to the development of various cancers by enabling constitutive kinase activation[2][5]. Human genetic variants disrupting TPR can result in intellectual disability and neurological syndromes; however, TPR itself is not a typical therapeutic target (such as a receptor or enzyme)[1][5]. There are currently no known directly interacting drugs, biomarkers, or approved therapeutic strategies aimed at TPR.

Other names

Nucleoprotein TPRMegatorNPC-associated intranuclear proteinTranslocated promoter region proteinMRT79Nuclear pore complex-associated protein TPRTumor potentiating region