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Target intelligence / Profile preview
Translocator Protein (18 kDa) (TSPO)
- Target
- TSPO
- Molecular classification
- Tryptophan-rich sensory protein, Mitochondrial membrane protein
01
Overview
The translocator protein (18 kDa), or TSPO, is a mitochondrial membrane protein involved in cholesterol transport, steroidogenesis, and apoptosis regulation. It is highly expressed in steroidogenic tissues and glial cells, and upregulated during neuroinflammation and cancer, making it a biomarker for these conditions. TSPO binds various ligands, offering therapeutic potential but also raising safety concerns.
- Other names
- Peripheral Benzodiazepine Receptor (PBR)
02
Mechanism of action
Ligand binding modulates cholesterol transport into mitochondria and steroid hormone synthesis.
03
Biological functions
Mitochondrial cholesterol transportSteroidogenesisPorphyrin transportHeme synthesisCell survivalApoptosis regulationCell proliferation
04
Disease associations
NeuroinflammationCancerNeurodegenerative diseaseCardiac disease
05
Safety considerations
Off-target effects of ligandsPotential for altered steroidogenesis
06
Interacting drugs
Diazepam
4 more in the full profile.
07
Biomarkers
Microglial activationAstrogliosisTumor aggressiveness
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