Transmembrane protease, serine 11F (TMPRSS11F)

Transmembrane protease, serine 11F (TMPRSS11F) is a type II transmembrane serine protease mainly found at the cell surface of diverse epithelial tissues and exocrine glands[1][2][3][5]. It plays an essential role in epidermal barrier formation and maintenance, facilitating proteolysis required for normal skin function and hydration[1][2][3]. Studies in knockout mice show its importance in preventing trans-epidermal fluid loss, especially in neonates[1][2]. Abnormal expression in cancer, specifically acute myeloid leukemia, is correlated with poor prognosis and promotes cancer cell invasion via activation of matrix metalloproteinase-2[1]. There are no documented drug interactions or approved targeted therapies, but the molecule is being explored as a cell surface biomarker and as a candidate therapeutic target in oncology[1][2][3][5].

Other names

TMPRSS11FHATL4Airway trypsin-like protease 4FLJ16046Transmembrane serine protease 11F

not established for approved drugs; mechanism described in cancer is activation of matrix metalloproteinase-2 facilitating cancer invasion[1]