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Transmembrane Protease, Serine 6 (TMPRSS6)
- Target
- TMPRSS6
- Molecular classification
- Enzyme, Serine Protease, Type II transmembrane serine proteinase
01
Overview
TMPRSS6/matriptase‐2 is essential for maintaining proper systemic iron balance through its negative regulation of hepatic hepcidin production. Loss-of-function mutations result in severe hereditary anemia due to unrestrained suppression of intestinal and tissue-derived plasma iron supply.
- Other names
- matriptase-2Matriptase 2Matriptase‐2Membrane-bound mosaic serine proteinase matriptase‐2Type II transmembrane serine protease 6
02
Mechanism of action
siRNA-mediated silencing of Tmprss6 led to increased hepatic hepcidin mRNA and reduced transferrin saturation
03
Biological functions
Negative regulator of hepcidinRegulation of iron homeostasisProteolytic processing of hemojuvelinPromotes dietary iron releasePromotes stored iron release
04
Disease associations
Iron-refractory Iron Deficiency Anemia (IRIDA)
05
Interacting drugs
RNAi targeting Tmprss6
1 more in the full profile.
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