Transmembrane protein 183B, pseudogene (TMEM183BP)

Transmembrane protein 183B, pseudogene (TMEM183BP) was originally identified as a pseudogene related to chromosome 1 open reading frame 37 (C1orf37) because it is intronless and retains a polyA tail at the 3’ end, but it contains a complete open reading frame that can be transcribed in a limited number of human tissues. The protein product, if expressed, may associate with cell membranes and could be involved in cell-cell or cell-environment interactions, but concrete molecular function and disease associations have not been demonstrated. The nomenclature and classification are complicated by overlap with TMEM183A, which is an actual protein-coding gene. TMEM183BP is not recognized as a validated receptor, enzyme, transporter, or therapeutic target[1]. Key points: - TMEM183BP is a pseudogene with possible but unproven protein-coding ability. - It is not a validated therapeutic target. - No drugs, known mechanisms, biomarkers, or safety information are associated. - The main confusion arises from its classification (“transmembrane protein”) and similarity in name to functional gene TMEM183A[3]. - No strong evidence links TMEM183BP to disease roles or biological pathways; most disease associations and functional data referenced in the literature actually refer to different TMEM family members[4].

Other names

Putative transmembrane protein 183BPTMEM183BPC1orf37-dupTMEM183BC1orf37-DUPTransmembrane protein 183B pseudogeneC1ORF37DUP