Transport and Golgi organization protein 1 homolog (TANGO1) (MIA3)

Transport and Golgi organization protein 1 homolog (TANGO1), encoded by the MIA3 gene, is a large scaffold/cargo receptor protein located at endoplasmic reticulum (ER) exit sites[1][2][3][4]. It orchestrates the export of large cargoes—especially collagens and lipoproteins—by organizing COPII coat assembly and recruiting additional membranes to form specialized carriers for bulky cargo. MIA3/TANGO1 is critical for the assembly and function of the early secretory pathway and the proper export of ECM proteins, especially collagens, which is essential for bone and connective tissue formation[1][2][4]. Disruption of MIA3 function leads to failure of collagen secretion, defects in bone mineralization, and broader disruptions to protein secretion. MIA3/TANGO1 also exhibits context-dependent roles in cancer, cardiovascular disease, and immune/inflammatory disorders. Its essential role in basic cellular physiology and lack of known drug interactors mean that it is not a direct therapeutic target at present, but it is a crucial regulator of secretory pathway homeostasis in mammals[1][2][3][4][5].

Other names

TANGO1MIA3KIAA0268Transport and Golgi organization protein 1 homologD320UNQ6077/PRO20088FLJ39207ODCD2ARNTMelanoma inhibitory activity protein 3MIA family member 3C219-reactive peptide

Not applicable, as no drugs are known to directly target this molecule.