tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A)

tRNA (uracil-5-)-methyltransferase homolog A (TRMT2A) is an S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the formation of 5-methyl-uridine (m5U), mainly at position 54 in cytosolic tRNAs, and in some cases in mRNAs[1][2][8]. This modification is important for tRNA stability and function, contributing to translational fidelity and efficient protein synthesis[2][7]. TRMT2A is predicted to function in methylation, tRNA processing, and mRNA processing and is localized primarily to the cytosol[3]. Aberrant expression of TRMT2A has been reported as a possible biomarker in breast mucinous carcinoma, with some evidence for a role in suppressing cell proliferation and regulating the cell cycle[1][5][9]. No approved drugs are currently known to target TRMT2A, nor are there established mechanisms of action or safety concerns associated with therapeutic targeting[1].

Other names

HpaII tiny fragments locus 9CHTF9CmRNA (uracil-5-)-methyltransferase TRMT2ATRM2 tRNA methyltransferase 2 homolog AhTRMT2AtRNA methyltransferase 2A