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tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (TARBP1)
- Target
- TARBP1
- Molecular classification
- Enzyme, Methyltransferase
01
Overview
tRNA (guanosine(18)-2'-O)-methyltransferase TARBP1 (TARBP1) is a S-adenosyl-L-methionine-dependent enzyme that catalyzes the formation of 2'-O-methylguanosine at position 18 in a subset of tRNA molecules, influencing tRNA structure and function. TARBP1 may also interact with RNA elements involved in HIV-1 gene regulation and has been implicated in cancer progression, particularly hepatocellular carcinoma, by affecting glutamine metabolism. TARBP1 belongs to the methyltransferase family and is broadly related to the regulation of RNA metabolism and posttranscriptional modification.
- Other names
- tRNA methyltransferase 3 homologTRM3TRMT3TRP-185TRP185TAR RNA-binding protein 1tRNA guanosine 2'-O-methyltransferase TARBP1TAR (HIV-1) RNA-binding protein 1probable methyltransferase TARBP1tRNA (guanine(18)-2'-O)-methyltransferaseTAR RNA loop binding protein
02
Mechanism of action
Not established for any approved drugs. General potential: drugs could act by inhibiting methyltransferase activity or modulating RNA-protein interactions
03
Biological functions
tRNA methylationCatalysis of 2'-O-methylguanosine formation at position 18 (Gm18) in tRNAPotential involvement in transcriptional elongation by disengaging RNA polymerase II from TAR element
04
Disease associations
Cancer (specifically hepatocellular carcinoma via metabolic reprogramming)Infection (potential role in HIV-1 regulatory element interaction)
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