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Target intelligence / Profile preview
Troponin C (Skeletal Muscle) (TnC)
- Target
- TnC
- Molecular classification
- Calcium-binding protein, Troponin subunit
01
Overview
Troponin C (TnC) is a calcium-binding protein that forms part of the troponin complex, which regulates contraction in striated muscle. In skeletal muscle, TnC acts as the primary calcium sensor, triggering conformational changes that enable actin-myosin interaction and thus muscle contraction. There are two main isoforms: TNNC1 (cardiac and slow-twitch skeletal) and TNNC2 (fast-twitch skeletal). TNNC2 has a higher affinity for Ca2+.
- Other names
- TNNC1TNNC2Troponin C type 1 (slow skeletal and cardiac)Troponin C type 2 (fast skeletal)
02
Mechanism of action
Calcium sensitization of fast skeletal troponins
03
Biological functions
Calcium bindingMuscle contraction regulationThin filament regulation
04
Disease associations
Neuromuscular disordersMuscular diseasesSarcopenia
05
Interacting drugs
CK-2017357
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