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Target intelligence / Profile preview
Tryptophan 2,3-dioxygenase (TDO)
- Target
- TDO
- Molecular classification
- Enzyme, Dioxygenase, Heme enzyme
01
Overview
Tryptophan 2,3-dioxygenase (TDO; EC 1.13.11.11) is a heme-containing enzyme that catalyzes the first and rate-limiting step in the kynurenine pathway of tryptophan metabolism, converting L-tryptophan to N-formyl-L-kynurenine. This reaction is crucial for regulating systemic tryptophan levels and has significant implications for immune and neurological homeostasis. TDO activity is tightly regulated by tryptophan levels: high tryptophan stabilizes tetrameric active conformation, while low tryptophan destabilizes tetramers leading to degradation. Dysregulation or aberrant expression has been implicated in digestive system diseases and cancer, making it a promising therapeutic target.
02
Mechanism of action
Inhibition of tryptophan 2,3-dioxygenase to increase tryptophan levels and modulate the kynurenine pathway
03
Biological functions
Tryptophan catabolismRegulation of tryptophan levelsKynurenine pathwayImmune regulationNeurological homeostasis
04
Disease associations
Digestive system diseasesCancerInflammationImmunologyOncology
05
Safety considerations
Potential for impacting tryptophan homeostasisOff-target effects due to structural similarity with other dioxygenases
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