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Tubulin (vinca domain)
- Molecular classification
- Cytoskeletal protein complex, Tubulin
01
Overview
The tubulin vinca domain is a specific binding site on the tubulin protein, a key component of microtubules. It is located at the interface between α- and β-tubulin subunits. This domain is the target for several antimitotic agents used in cancer therapy, such as vinca alkaloids (e.g., vinblastine, vincristine). Drugs targeting the vinca domain inhibit microtubule polymerization, leading to mitotic arrest and apoptosis in rapidly dividing cells.
02
Mechanism of action
Inhibits microtubule polymerization by stabilizing curved protofilament assemblies, leading to mitotic arrest and apoptosis.
03
Biological functions
Microtubule formationMicrotubule dynamicsMitosisIntracellular transportCell shape maintenance
04
Disease associations
Cancer
05
Safety considerations
Drug resistanceToxicity
06
Interacting drugs
Vinblastine
4 more in the full profile.
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