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Tubulin beta chain (Vinca-Binding Site) (TUBB (Vinca site))
- Target
- TUBB (Vinca site)
- Molecular classification
- Microtubule protein, Structural protein
01
Overview
The tubulin beta chain is a core component of microtubules, essential for cell shape, intracellular transport, and mitosis. The vinca-binding site on the beta subunit interacts with antimitotic agents like vinca alkaloids, disrupting microtubule dynamics and inhibiting cell division. This is exploited in cancer chemotherapy. The binding site is located at the interface of alpha- and beta-tubulin.
- Other names
- Tubulin beta chainVinca domainVinblastine binding site
02
Mechanism of action
Microtubule destabilization by inhibiting polymerization and disrupting tubulin dynamics
03
Biological functions
MitosisChromosome segregationIntracellular transportCell shape maintenanceGTP binding
04
Disease associations
CancerNeurodegenerative disease (implicated)
05
Safety considerations
Neurotoxicity (vinca alkaloids)Myelosuppression (vinca alkaloids)Drug resistance
06
Interacting drugs
Vinblastine
4 more in the full profile.
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