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Target intelligence / Profile preview
Tumor Antigen (Solid Tumor) (TA)
- Target
- TA
- Molecular classification
- Protein, Glycoprotein, Cell Surface Marker
01
Overview
Tumor antigens in solid tumors are molecules—often proteins or glycoproteins—expressed on the surface of cancer cells. These antigens can be recognized by the immune system and are key targets for immunotherapies. They are generally tumor-associated antigens (TAAs), overexpressed on tumor cells but potentially present in some normal tissues, or neoantigens arising from tumor-specific mutations. Heterogeneous expression and potential for off-target effects pose challenges for therapeutic targeting.
- Other names
- Tumor-Associated Antigen (TAA)Neoantigen
02
Mechanism of action
Binding to tumor cell surface, mediating immune cell activation or direct cytotoxicity
03
Biological functions
Immune recognitionTarget for immunotherapyCell signaling
04
Disease associations
Cancer
05
Safety considerations
On-target/off-tumor toxicityCytokine release syndrome (CRS)NeurotoxicityTumor lysis syndromeImmunosuppression in tumor microenvironment
06
Interacting drugs
CAR-T cell therapies
3 more in the full profile.
07
Biomarkers
EGFR expressionHER2 expressionMesothelin expressionGD2 expressionCEA expressionIL13Rα2 expression
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