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Tumor-associated antigen: mucin 1 carrying the Tn antigen
- Molecular classification
- Glycoprotein neoepitope, MUC1 glycoform
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Overview
MUC1-TN refers to a tumor-associated glycoform of the mucin 1 (MUC1) protein, characterized by the presence of the Tn antigen—a truncated O-linked N-acetylgalactosamine (GalNAc) sugar. This aberrant glycosylation is not found in healthy tissues but is commonly present on MUC1 expressed by various epithelial cancers, making it a highly specific marker and target for cancer immunotherapy. In tumors, it promotes cell proliferation, enhances survival signaling, facilitates invasion/metastasis, and contributes to immune evasion due to its altered surface presentation.
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Mechanism of action
Specific binding to tumor cells expressing MUC1-TN, inducing cytotoxicity (CAR T cells, antibodies); eliciting CTL/ADCC responses (vaccines).
03
Biological functions
Oncogenic signaling modulationImmune evasionCell proliferationEnhances survival signalingFacilitates invasion/metastasis
04
Disease associations
CancerTumor progressionMetastasis
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Safety considerations
Circulating shed forms of MUC1-TN may act as decoys for antibody therapies
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Interacting drugs
CAR T Cells targeting MUC1-TN
2 more in the full profile.
07
Biomarkers
Diagnostic marker for breast cancerDiagnostic marker for lung cancerDiagnostic marker for gastric cancerPrognostic marker for advanced tumor stagePrognostic marker for metastasis risk
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