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Tumor-Associated Antigen (Autologous)
- Molecular classification
- Protein, Peptide, Glycoprotein
01
Overview
Tumor-associated antigens (TAAs) are cellular proteins that are abnormally expressed, mutated, or otherwise altered in tumor cells compared to normal tissues. When these antigens originate from the patient's own tumor cells, they are referred to as *autologous* TAAs. These molecules can trigger an immune response because their abnormal presence or structure is recognized as non-self by the host's immune system. Autologous TAAs serve as both biomarkers for detection/monitoring and targets for personalized immunotherapy approaches in oncology.
- Other names
- Autologous TAATAA (autologous)Patient-specific Tumor Antigen
02
Mechanism of action
Stimulation of anti-tumor immune response via autoantibody production and cytotoxic T lymphocyte (CTL) activation.
03
Biological functions
Immune responseAntigen presentationTumor growthCell deathTarget for immunotherapy
04
Disease associations
Cancer
05
Safety considerations
Potential for autoimmune reactions due to cross-reactivity with normal tissuesOn-target, off-tumor toxicityCytokine release syndrome (CRS)Tumor lysis syndrome (TLS)
06
Biomarkers
Autoantibody levels against specific TAAsPresence/absence of specific TAAs in tumor tissueImmune cell infiltration in tumor microenvironmentT cell receptor (TCR) repertoire analysis
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