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Target intelligence / Profile preview
Tumor Cell (Selective Viral Replication) (N/A)
- Target
- N/A
- Molecular classification
- Cell, Virus, Other
01
Overview
Tumor-selective viral replication leverages the altered transcriptional landscape, surface marker expression, metabolic changes, and immune evasion characteristics of malignant versus healthy tissue. This approach ensures that the cytolytic effects—and any delivered therapeutic transgenes—are focused on neoplastic lesions while minimizing off-target toxicity.
- Other names
- Oncolytic Virus TargetCancer Cell (Selective Viral Replication)Tumor-Selective Viral ReplicationSelective Viral Replication in Tumor Cells
02
Mechanism of action
Selective viral replication and lysis of tumor cells, induction of immunogenic cell death.
03
Biological functions
Cell deathViral replicationImmune responseTumor cell lysis
04
Disease associations
Cancer
05
Safety considerations
Off-target viral replicationImmune response against the virusInsertional mutagenesisPotential for viral shedding and transmission
06
Interacting drugs
Oncolytic Viruses (e.g., Adenovirus, Vaccinia Virus, Measles Virus, Herpes Simplex Virus)
07
Biomarkers
Tumor-specific promoter activity (e.g., hTERT)Expression levels of viral entry receptors (e.g., CAR, CD46, CD155)Defects in antiviral signaling pathways (e.g., interferon signaling)Thymidine kinase (TK) activityPresence of specific tumor antigens for immune monitoring
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