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Tumor cell DNA (via methylation)
- Molecular classification
- Epigenetically modified genomic DNA
01
Overview
Tumor cell DNA methylation refers to the aberrant methylation patterns observed in the DNA of cancer cells, characterized by hypermethylation of tumor suppressor genes and global hypomethylation. These epigenetic modifications play a crucial role in regulating gene expression and contribute to oncogenesis. Detection of these aberrant methylation patterns serves as a valuable biomarker for cancer diagnostics and monitoring, and targeting DNA methylation is an area of active therapeutic investigation.
- Other names
- Methylated tumor DNATumor DNA methylationCirculating tumor DNA methylation (ctDNA methylation)
02
Mechanism of action
DNA methylation inhibition
03
Biological functions
Regulation/silencing/activation of gene expressionMaintenance/inheritance during replicationGene silencingGenomic instability
04
Disease associations
Cancer
05
Safety considerations
Off-target effects of DNMT inhibitorsPotential for non-specific demethylationDevelopment of resistance to demethylating agents
06
Interacting drugs
DNMT inhibitors
1 more in the full profile.
07
Biomarkers
Methylated circulating tumor DNA fragmentsPromoter hypermethylation of tumor suppressor genesGlobal DNA hypomethylation
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