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Tumor Microvasculature (Liver) (N/A)
- Target
- N/A
- Molecular classification
- Vasculature, Tumor Microenvironment, Extracellular matrix
01
Overview
The tumor microvasculature in the liver refers to the abnormal network of small blood vessels that form within and around liver tumors, particularly hepatocellular carcinoma (HCC). This vasculature supports tumor growth, progression, invasion, and metastasis through enhanced angiogenesis. It is characterized by disorganized architecture, deficient pericyte coverage, and leaky endothelium. Targeting the aberrant microvasculature is a major therapeutic strategy in HCC, but resistance can develop. Markers such as MVD are used prognostically.
- Other names
- Liver Tumor VasculatureHepatic Tumor MicrovasculatureHCC MicrovasculatureTumor Angiogenesis (Liver)
02
Mechanism of action
Inhibition of angiogenesis via VEGF pathway blockade; multi-kinase inhibition
03
Biological functions
AngiogenesisNutrient supply to tumor cellsWaste removal from tumor cellsMetastasisEndothelial cell proliferationVascular permeability
04
Disease associations
Hepatocellular carcinoma (HCC)Liver cancerTumor progressionMetastasis
05
Safety considerations
Resistance to anti-angiogenic therapiesHemorrhageHypertensionImpaired wound healing
06
Interacting drugs
Bevacizumab
1 more in the full profile.
07
Biomarkers
Microvessel density (MVD) assessed by CD34 or CD105 immunostaining
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