Tumor necrosis factor receptor type 1-associated death domain protein mRNA 3' untranslated region (TRADD mRNA 3'UTR) (TRADD mRNA 3'UTR)

Tumor necrosis factor receptor type 1-associated death domain protein (TRADD) is a vital adapter molecule in the TNF-alpha signaling pathway, serving as a scaffold for both pro-survival NF-kappaB activation and pro-death apoptotic or necroptotic signaling (Source: UniProt P46531). The 3' untranslated region (3'UTR) of TRADD mRNA contains regulatory sequences that determine the stability and translation of the transcript, making it a strategic target for RNA-based therapeutics (Source: PubMed 22438544). Antisense oligonucleotides (ASOs) designed to hybridize with the TRADD mRNA 3'UTR can trigger RNase H-mediated degradation, effectively lowering TRADD protein levels and dampening TNF-induced inflammation and cell death (Source: PubMed 26133978). This target is of significant interest in treating chronic inflammatory diseases like psoriasis and neurodegenerative conditions such as Amyotrophic Lateral Sclerosis (ALS), where TRADD-mediated necroptosis contributes to disease progression (Source: PubMed 28842572). Experimental studies have demonstrated that reducing TRADD expression via 3'UTR-targeted ASOs can protect against systemic inflammatory response syndrome and localized tissue damage in animal models (Source: PubMed 26133978). By specifically targeting the 3'UTR, researchers can achieve potent knockdown of the TRADD protein, providing a therapeutic window to modulate TNF-mediated pathologies without completely abolishing the immune response.

Other names

TRADD 3'UTRTNFRSF1A-associated via death domain mRNA 3'UTRTRADD mRNA 3-prime untranslated region

Antisense oligonucleotides bind to the 3'UTR of TRADD mRNA, leading to RNase H-mediated degradation of the transcript and subsequent reduction in TRADD protein synthesis.