Type I interferon receptor (composed of IFNAR1 and IFNAR2) (IFNAR (sometimes IFNAR1/IFNAR2 for subunits))

The Type I interferon receptor is a heterodimeric membrane receptor complex composed of the IFNAR1 and IFNAR2 subunits, which specifically binds type I interferons (including IFNα, IFNβ, and related molecules). Upon ligand binding, the receptor activates the JAK-STAT signaling pathway, resulting in transcriptional changes that mediate antiviral, antiproliferative, and immune-modulating responses. This receptor is a central mediator of immune responses to viral infections and is targeted therapeutically in cancer, multiple sclerosis, and other diseases relating to immune dysfunction.

Other names

Interferon alpha/beta receptorIFNAR1 (subunit name)IFNAR2 (subunit name)Interferon-α/β receptorIFN-alpha/betaR

Ligand binding to IFNAR1/IFNAR2 complex induces intracellular signaling via JAK-STAT pathway, leading to transcription of interferon-stimulated genes and antiviral, antiproliferative, and immunomodulatory effects