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Type II DNA Topoisomerase (Topoisomerase IV) (None)

Target: None
Molecular classification: Enzyme, Type IIA topoisomerase

Overview

Type II DNA topoisomerases such as Topo IV are indispensable enzymes that maintain genomic stability in bacteria through their unique ability to introduce transient double-strand breaks into duplex DNA. Their critical roles make them prime targets for antibacterial therapy due to their absence from human cells but essentiality in bacteria.

Other names: Topo IVTopoisomerase IVDNA gyrase subunit ParCDNA gyrase subunit ParE

Mechanism of action

Stabilization of enzyme-DNA cleavage complexes leading to cell death

Biological functions

DNA topology alterationChromosome segregationDecatenationRelaxation of positive supercoilsDNA replicationMaintenance of chromosome integrity

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Infection

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Resistance development

Interacting drugs

Fluoroquinolones

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